For two centuries, economics quietly assumed everyone in a market knew what they were buying. Akerlof asked the obvious unasked question: what if they don't? If a buyer can't tell a sound used car from a lemon, they'll only pay an average price — too low for the good cars, too high for the bad. Owners of good cars withdraw; the average quality drops; the fair price drops with it; more good cars leave. The market can unravel completely.
This is adverse selection, and it lurks wherever one side knows more than the other: health insurance (the people most eager to buy are often the least healthy), lending, online marketplaces, hiring. Akerlof's small paper founded the economics of information — the recognition that asymmetric knowledge is not a minor friction to be ignored, but a force strong enough to destroy a market outright. The question was no longer just what is it worth? but who knows?